EOMIN is unique

Not all neurotoxins are the same1-4, despite what your patients may think.

Xeomin® is unique. It was the first clinically proven anti-wrinkle injection uniquely purified to remove proteins unnecessary for treatment.*

Xeomin is indicated for temporary improvement in the appearance of moderate to severe glabellar lines in adult patients. Xeomin can help differentiate your practice.5 Xeomin is different in ways that matter to you and to your patients.5

*Studies have not been performed to determine whether the presence or absence of complexing/unnecessary proteins has a long-term effect on safety or efficacy.

Mechanism of Action

  • Xeomin® is a Botulinum Toxin Type A that blocks transmission of acetylcholine (ACh) from neuron to muscle
  • This inhibits muscle contraction and causes muscle paresis (weakness) or paralysis
  • Botulinum Toxin Type A only affects "cholinergic neurons" (neurons which use acetylcholine as a neurotransmitter)
  • Botulinum Toxin Type A effects dissipate after ~ 3 months because new SNAP-25 proteins take 3 months to be synthesized1

Xeomin Botulinum toxin type A molecule Xeomin®
150 kDa
molecule - Botulinum toxin (tyBotulinum toxin type A molecule Botulinum toxin (type A)
900 kDa


Our precise manufacturing process

Xeomin is uniquely purified and precisely manufactured in a German facility using advanced technology to isolate the therapeutic component.

Exacting standards

The active ingredient of Xeomin is botulinum toxin type A, produced from fermentation of Hall strain Clostridium botulinum serotype A. Merz takes the toxin complex and employs a precise manufacturing process that isolates the therapeutic component and removes the complexing/unnecessary proteins to produce Xeomin. Complexing/unnecessary proteins accompany the active neurotoxin but do not play an active role in treatment. Studies have not been performed to determine whether the presence or absence of complexing/unnecessary proteins has a long-term effect on safety or efficacy.

  1. Xeomin® (incobotulinumtoxinA) for injection, for intramuscular use. Prescribing Information. Merz Pharmaceuticals, LLC, 2020.
  2. Dysport® (abobotulinumtoxinA). Prescribing Information. Medicis Pharmaceutical Corporation. 2015.
  3. Bigalke H. Properties of pharmaceutical products of botulinum neurotoxins. In: Jankovic J et al. Botulinum Toxin: Therapeutic Clinical Practice and Science. Philadelphia, PA: Elsevier 2009.
  4. Wenzel R, Jones D, Borrego JA. Comparing two botulinum toxin type A formulations using manufacturers' product summaries. J Clin Pharm and Therapeutics. 2007;32:387-402.
  5. Frevert J. Drugs R D. 2015;15:1-9.


XEOMIN® (incobotulinumtoxinA) for injection, for intramuscular use is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines with corrugator and/or procerus muscle activity in adult patients.


See full prescribing information for complete BOXED WARNING.

The effects of XEOMIN® and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms.




Glabellar Lines: The most commonly observed adverse reaction (incidence ≥ 2% of patients and greater than placebo) for XEOMIN® was Headache (5.4%).


Co-administration of XEOMIN® and aminoglycoside antibiotics or other agents interfering with neuromuscular transmission, e.g., tubocurarine-type muscle relaxants, should only be performed with caution as these agents may potentiate the effect of the toxin.
Use of anticholinergic drugs after administration of XEOMIN® may potentiate systemic anticholinergic effects. The effect of administering different botulinum toxin products at the same time or within several months of each other is unknown. Excessive neuromuscular weakness may be exacerbated by administration of another botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin.


There are no adequate data on the developmental risk associated with the use XEOMIN® in pregnant women. XEOMIN should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


Safety and effectiveness of XEOMIN® in patients less than 18 years of age have not been established.

XEOMIN® is available only through licensed physicians.

Enter your zip code to find a licensed XEOMIN® provider.